Pilot Kiran Bhattarai and co-pilot Aditya Nepali were killed when the Makalu Air cargo aircraft crashed at Simikot pass in Bahun Kharka in Humla district, police said.
The bodies of the two pilots have been brought to Kathmandu. There were no other passengers in the ill-fated aircraft, police said.
The bodies were brought on board a Simrik Air helicopter at around 1 pm, said Simrik Air staffer Kamal Gautam.
The aircraft took off from Surkhet Airport early today and was scheduled to land at 6:55 am in Simikot.
Makalu Air has three single-engine Cessna 208B Grand Caravan aircrafts to its fleet. Based in Nepalgunj, Makalu Air provides chartered passenger and cargo services.
The freight transporter aircraft was discovered wrecked and fragmented into three parts in Ekalbajkharka at around 11:00 am, a Nepalese media report said.
The plane was mostly used for flying food and other supplies in the mountainous region.